Pinpointing the neural signatures of single-exposure visual recognition memory

V Mehrpour, T Meyer, E P Simoncelli and N C Rust

Published in Proc. Nat'l Academy of Sciences, vol.118(18), May 2021.

DOI: 10.1073/pnas.2021660118

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  • Memories of the images that we have seen are thought to be reflected in the reduction of neural responses in high-level visual areas such as inferotemporal (IT) cortex, a phenomenon known as repetition suppression (RS). We challenged this hypothesis with a task that required rhesus monkeys to report whether images were novel or repeated while ignoring variations in contrast, a stimulus attribute that is also known to modulate the overall IT response. The monkeyss' behavior was largely contrast-invariant, contrary to the predictions of an RS-inspired decoder, which could not distinguish responses to images that are repeated from those that are of lower contrast. However, the monkeys' behavioral patterns were well-predicted by a linearly decodable variant in which the total spike count was corrected for contrast modulation. These results suggest that the IT neural activity pattern that best aligns with single-exposure visual recognition memory behavior is not RS but rather ``sensory referenced suppression (SRS)'': reductions in IT population response magnitude, corrected for sensory modulation.
  • Superseded Publications: Mehrpour20b, Mehrpour20a, Mehrpour19a
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