A blind sparse deconvolution method for neural spike identification

C Ekanadham, D Tranchina and E P Simoncelli

Published in Adv. Neural Information Processing Systems (NIPS*11), vol.24 pp. 1440--1448, Dec 2011.

This paper has been superseded by:
A unified framework and method for automatic neural spike identification
C Ekanadham, D Tranchina and E P Simoncelli.
J. Neuroscience Methods, vol.222 pp. 47--55, Jan 2014.


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  • We consider the problem of estimating neural spikes from extracellular voltage recordings. Most current methods are based on clustering, which requires substantial human supervision and systematically mishandles temporally overlapping spikes. We formulate the problem as one of statistical inference, in which the recorded voltage is a noisy sum of the spike trains of each neuron convolved with its associated spike waveform. Joint maximum-a-posteriori (MAP) estimation of the waveforms and spikes is then a blind deconvolution problem in which the coefficients are sparse. We develop a block-coordinate descent procedure to approximate the MAP solution, based on our recently developed continuous basis pursuit method. We validate our method on simulated data as well as real data for which ground truth is available via simultaneous intracellular recordings. In both cases, our method substantially reduces the number of missed spikes and false positives when compared to a standard clustering algorithm, primarily by recovering overlapping spikes. The method offers a fully automated alternative to clustering methods that is less susceptible to systematic errors.
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