| Program#/Poster#: |
406.19/YY88 |
| Title: |
Neurophysiological
correlates of time encoding in the amygdalo-prefronto-striatal network |
| Location: |
Hall A-C |
| Presentation Time: |
Monday, Nov 14, 2011, 10:00
AM -11:00 AM |
| Authors: |
*J. KNIPPENBERG1,
M. GRAUPNER2, L. DIAZ-MATAIX2, J. E. LEDOUX2,3,
V. DOYERE1;
1Ctr. De Neurosciences Paris-Sud, Cnrs-Umr8195, Univ. Paris-Sud,
Orsay, France; 2Ctr. for Neural Science, New York Univ., New
York, NY; 3Emotional Brain Institute, Nathan S. Kline Inst. for
Psychiatry Res., New York, NY |
| Abstract: |
In associative learning
paradigms such as Pavlovian conditioning an organism not only learns that
stimulus A predicts stimulus B, it also learns when stimulus B is presented.
Recent experimental reports indicate that the amygdala might be involved
in this kind of temporal encoding. On the other hand, prefrontal cortex
and dorsal striatum are thought to be involved in temporal processing. In
the current study we investigated the role of the basal amygdala and its
projections to the dorsal striatum and prefrontal cortex in learning the
time of arrival of a footshock unconditioned stimulus (US) during auditory
fear conditioning in rats. Using a conditioned suppression paradigm (with
lever pressing for food as the instrumental basis), rats were trained on
a discrimination protocol in which two different tones (1 kHz and 11 kHz)
were associated with two different times of US arrival (10 and 30 sec).
Non-reinforced trials (tones without shocks) were introduced to assess the
temporal pattern of suppression. After overtraining, when temporal behavior
was observed, local field potentials were recorded simultaneously from amygdala,
striatum and prefrontal cortex while the animal was subjected to this protocol.
Oscillatory activities within different frequency ranges (delta, theta,
beta, gamma) were analyzed in relation to the expected time of the US in
each of these structures. In addition, we investigated temporal changes
in coherence between the neural activities in these structures. Thus, our
study determines whether the basal amygdala, the prefrontal cortex and/or
the dorsal striatum show neural correlates of CS-US interval encoding and
tests for their functional connectivity in a Pavlovian fear conditioning
paradigm. |
| |
|
|
|
|
|
|
|
|
|