| Program#/Poster#: |
479.27/FF128 |
| Title: |
Sex differences and estrogen effects
on retrieval of conditioned fear extinction |
| Location: |
South Hall A |
| Presentation Time: |
Monday, Oct 19, 2009, 3:00 PM - 4:00
PM |
| Authors: |
*R. SHANSKY1, J. H. MORRISON1,
J. LEDOUX2;
1Dept Neurosci, Mount Sinai Sch. Med., New York, NY; 2Ctr. for Neural Sci.,
New York Univ., New York, NY |
| Abstract: |
The mechanisms underlying fear conditioning,
extinction and extinction retrieval have been well-studied in male animals,
but these important learning processes have only begun to be explored in
females. Women are more susceptible to Major Depressive Disorder and Post-Traumatic
Stress Disorder, mental illnesses that may be manifest in part by a dysfunction
of the neural circuitry that governs these experimental models. In the current
study, male rats and ovariectomized (OVX) female rats with (OVX + E) and
without (OVX + veh) estrogen replacement were tested on fear conditioning,
extinction and extinction recall. Preliminary data suggest that OVX + veh
animals display less freezing behavior during training than either males
or OVX + E, and that females (regardless of hormone status) extinguish faster
than males. |
| Support: |
NIH P50 MH58911 |
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