UI  - 0
AU  - Kautz D
AU  - Wagner H
TI  - GABAergic Inhibition Influences Auditory Motion-Direction Sensitivity
      in Barn Owls.
LA  - ENG
PT  - JOURNAL ARTICLE
DA  - 19980710
DP  - 1998 Jul
IS  - 0022-3077
TA  - J Neurophysiol
PG  - 172-85
IP  - 1
VI  - 80
JC  - JC7
AB  - GABAergic inhibition influences auditory motion-direction sensitivity
      in barn owls. J. Neurophysiol. 80: 172-185, 1998. Many neurons in the
      barn owl's inferior colliculus (IC) exhibit auditory motion-direction
      sensitivity (MDS), i.e., they respond more to motion of a sound source
      in one direction than to motion in the opposite direction. We
      investigated the cellular mechanisms underlying the phenomenon of
      auditory MDS by microiontophoretically applying gamma-aminobutyric acid
      (GABA) or the GABA-antagonist bicuculline methiodide (BMI) while
      recording from neurons in the owl's midbrain. In most cases GABA
      reduced the overall firing rate, whereas BMI increased it. In addition,
      29% of the motion-direction-sensitive cells completely lost their
      selectivity for the direction of auditory movement during
      administration of BMI. It had been proposed that auditory MDS in the
      owl is due to inhibition. The present results show that GABAergic
      inhibition plays a role in the strengthening of MDS. We discuss the
      data within the framework of the acoustic motion detector and with
      respect to microiontophoretic studies on visual motion detection and on
      inhibitory mechanisms in the inferior colliculus.
AD  - Max-Planck-Institut f#r biologische Kybernetik, D-72076 T#bingen,
      Germany and Institut f#r Zoologie, Technische Universit#t M#nchen, D-
      85747 Garching, Germany.
PMID- 0009658039
SO  - J Neurophysiol 1998 Jul;80(1):172-85

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