Neuron, Vol. 25, 109–121, January, 2000, Copyright © 2000 by Cell Press

Compromised Neural Selectivity for Song in Birds with Impaired Sensorimotor Learning

Michele M. Solis1 and Allison J. Doupe1
1 Keck Center for Integrative Neuroscience and Departments of Psychiatry and Physiology, University of California, San Francisco, San Francisco, California 94143


Corresponding author: Allison J. Doupe*, 415 476 6446 (phone), 415 502 4848 (fax), ajd@phy.ucsf.edu

Anterior forebrain (AF) neurons become selective for song as songbirds learn to produce a copy of a memorized tutor song. We report that development of selectivity is compromised when birds are prevented from matching their output to the tutor song. Finches with denervated vocal organs developed stable song, but it usually did not resemble the tutor song. In those birds, numerous neurons in Area X responded selectively to both tutor and birds own song (BOS), indicating the importance of both in shaping AF responses. The degree of selectivity for BOS was less, however, than that of normal adults. In contrast, neurons in denervated birds that successfully mimicked tutor song exhibited normal adult selectivity for BOS. Thus, during sensorimotor learning, selectivity for complex stimuli may be influenced by how well motor output matches internal sensory models.