UI  - 95403709
AU  - Malmierca MS
AU  - Rees A
AU  - Le Beau FE
AU  - Bjaalie JG
TI  - Laminar organization of frequency-defined local axons within and
      between the inferior colliculi of the guinea pig.
LA  - Eng
MH  - Acoustic Stimulation
MH  - Animal
MH  - Axons/*ultrastructure
MH  - Female
MH  - Guinea Pigs/*anatomy & histology
MH  - *Image Processing, Computer-Assisted
MH  - Inferior Colliculus/*ultrastructure
MH  - Lysine/analogs & derivatives
MH  - Male
MH  - Support, Non-U.S. Gov't
RN  - 56-87-1 (Lysine)
RN  - 576-19-2 (biocytin)
PT  - JOURNAL ARTICLE
DA  - 19951017
DP  - 1995 Jun 19
IS  - 0021-9967
TA  - J Comp Neurol
PG  - 124-44
SB  - M
CY  - UNITED STATES
IP  - 1
VI  - 357
JC  - HUV
AA  - Author
EM  - 199512
AB  - We present a comprehensive description of the local (intrinsic and
      commissural) connections in the central nucleus of the inferior
      colliculi (CNICs) in guinea pig. Focal injections of the anterograde
      tracer biocytin were made into physiologically identified loci of the
      CNIC and the spatial organisation of the labeled fibres was revealed
      with computer-assisted three-dimensional (3-D) reconstruction. The
      intrinsic fibres form a series of V-shaped laminar plexuses composed of
      fibres bearing both terminal and en passant boutons. Each laminar
      plexus has a central wing located in the CNIC that extends into the
      dorsal cortex and an external wing located in the external cortex. The
      edge where the two wings intersect delimits the lateral border of the
      central nucleus with the external cortex. The density of labeled
      terminals was consistently lower in the cortices than in the CNIC. The
      laminar plexus connects points of similar frequency within the CNIC.
      Seen in 3-D, the location, orientation, shape, and area of the laminar
      plexus vary as a function of best frequency. The commissural fibres
      ending in the contralateral IC to the injection also form a laminar
      plexus which is symmetrical to the ipsilateral plexus. Electrolytic
      lesions placed in the contralateral IC at sites with best frequencies
      corresponding to those of the injection coincided with the terminals of
      the commissural fibres in most instances. Possible patterns for the
      organisation of these connections (point-to-point and diverging) are
      discussed. Three systems of peripheral axons to the laminar plexus are
      described: parallel, oblique, and perpendicular to the central wing.
      The novel parallel system has terminals in both ICs that run parallel
      to the central wing. It might constitute the anatomical basis for
      across-frequency interactions. The oblique and perpendicular systems
      are fibres of passage projecting to the commissure and brachium of the
      IC, respectively.
AD  - Department of Physiological Sciences, Medical School, University of
      Newcastle Upon Tyne, United Kingdom.
PMID- 0007673462
SO  - J Comp Neurol 1995 Jun 19;357(1):124-44

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