G80/G83.2201 Cellular, Molecular & Developmental Neural Science FALL 2002
SYLLABUS
The class will meet in Room 815 Meyer Hall, Tuesdays and Thursdays 9:00-11:00AM.
G80/G83.2201 Cellular, Molecular & Developmental Neural Science FALL 2002
The class will meet in Room 815 Meyer Hall, Tuesdays and Thursdays 9:00-11:00AM.
Sep 5 Lect 1 Nerve and glia: structure and function (Aoki)
Readings: Hall, Ch 1; Feldman et al., Ch 3Sep 10 Lect 2 Ultrastructure of neurons & supporting cells (Aoki)
Readings: Palay, 1991; Feldman et al., Ch 6
Written assignment: due Sep 17Sep 12 Lect 3 Membrane biophysics I: Thermodynamic principles (Tranchina)
Readings: Fain, TBASep 17 Lect 4 Passive properties of the membrane. (Tranchina)
Readings: Fain, TBA
Written assignment: due Sep 24Sep 19 Lect 5 Diversity of ion channels: effect on firing patterns (Shapley)
Readings: Fain, TBASep 24 Lect 6 Quantal hypothesis of synaptic transmission: neuromuscular junction as a model (Tranchina)
Readings: Fain, TBA
Written assignment: due Oct 1Sep 26 Lect 7 Pre- and postsynaptic mechanisms of plasticity at excitatory synapses of the CNS (Shapley)
Readings: Fain, TBA
Oct 1 Lect 8 Neurotransmitters & receptors I: Glutamate for learning and memory but also excitotoxicity (Aoki)
Readings: Feldman et al., Ch 10.1
Written assignment: due Oct 10Oct 3 Lect 9 Neurotransmitters & receptors II: Function and plasticity of inhibitory synapses (Sanes and Kotak)
Readings: Feldman et al., Ch 10.2 and hand-outsOct 8 Lect 10 Neurotransmitters & receptors III: Noradrenaline (Aoki)
Readings: Feldman et al., Ch 8.1, 8.3, 12.1Oct 10 Lect 11 Neurotransmitters & receptors IV: Acetylcholine in sleep, memory and addiction (Aoki)
Readings:Feldman et al., Ch 7 and 20.2
Written assignment: due Oct 22Oct 15 Open date Oct 17 Lect 12 Neurotransmitters & receptors VI: Serotonin (Azmitia)
Readings: Azmitia & Whitaker-Azmitia, 1998Oct 22 Lect 13 Second messenger modulation of ion channels (Shapley)
Readings: Feldman et al., Ch 6; Jan & Jan; Wickman & Clapham, 1995
Written assignment: due Nov 12Oct 24 Open Date Oct 29 Lect 14 Genetic approach to Retinal development in Drosophila (Desplan)
Readings: Bate & Martinez-Arias, Chs 22,23 and 24, pp. 1277-1492Oct 31 Open Date Nov 5 No Class Society for Neuroscience Meeting Nov 7 Lect 15 Patterning of the retina for color vision (Desplan)
Written assignment: due Nov 19Nov 12 Lect 16 Molecular mechanisms of synaptic regulation (Ziff)
Readings: Ziff 1997; Shi et al., 1999; Tu et al., 1999Nov 14 Lect 17 Molecules to behavior: genetic approaches to study neural circuits (Holmes)
Readings:Nitabach, Blau, and Holmes (2002); van den Pol and Obrietan (2002).Nov 19 Lect 18 Development of the nervous system I: Neural cell death (Sanes)
Readings: Sanes et al., Ch 7
Written assignment: due Dec 5Nov 21 Lect 19 Development of the nervous system II: Formation of Maps (Sanes)
Readings: Sanes et al., Ch 6Nov 26 Lect 20 Development of the nervous system III: Synapse formation (Sanes)
Readings: Sanes et al., Ch. 8
Nov 28 No Class Thanksgiving Holiday
Dec 3 Lect 21 Development of the nervous system IV: Developmental Plasticity (Sanes)
Readings: Sanes et al., Ch 9
Dec 5 Lect 22 Neurotransmitters & receptors V: Dopamine and peptides (Johnson)
Readings: Feldman et al., Ch 8.2, 18, 20; Ch 11 and 12
Dec 10 Open Date
Dec 10 FINAL TAKE-HOME EXAM DISTRIBUTED TODAY; DUE DEC 21 AT 9:00AM.
FACULTY
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Chiye Aoki, 1056 Meyer, 8-3929 |
Vibhakar Kotak, 1007 Meyer, 8-3916 |
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Efrain Azmitia, Biology, 953 Brown, 8-8250 |
Dan Sanes, 1008 Meyer, 8-3924 |
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Claude Desplan, Biology, 756 Brown, 8-3966 |
Robert Shapley, 1059 Meyer, 8-7798 |
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Samuel Feldman†, 954 Meyer, 8-7852 |
Daniel Tranchina, 857A Brown, 8-8261 |
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Todd C. Holmes, Biology, 1009 Main, 8-8275 |
Edward Ziff, Biochemistry, NYU Med, 263-5774 |
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Luke Johnson, 1105 Meyer, 8-3624 |
† Course Director |
TEXTS:
Gordon L. Fain, Molecular and Cellular Physiology of Neurons, Cambridge, MA: Harvard University Press, 1999.
R.S. Feldman, J.S. Meyer and L.F. Quenzer, Principles of Neuropharmacology, Sunderland, MA: Sinauer, 1997.
D.H. Sanes, T.A. Reh and W.A. Harris, Development of the Nervous System, Academic Press, 2000.
OTHER READINGS (will usually be distributed):
Azmitia, EC and Whitaker-Azmitia, PM. Development and adult plasticity of serotonergic neurons and their target cells. Chapter 1 in HG Baumgarten and M Gothert (eds), Handbook of Experimental Pharmacology, NY: Elsevier, 1997.
Brandon, Idzerda, and McKnight (1997). PKA isoforms, neural pathways, and behavior:making the connection. Current Opinion in Neurobiology, 7(3):397-403.
Bray (1995). Protein molecules as computational elements in living cells. Nature, 376:307-312.
Cohen, Ren, and Baltimore (1995). Modular binding domains in signal transduction proteins. Cell, 80:237-248
Hall, ZW. Introduction to Molecular Neurobiology, Sunderland, MA: Sinauer, 1992 (Handout).
Jan, LY and Jan, YN. Receptor-regulated ion channels. Current Opinion in Neurobiology, (Handout)
Johnson, Noble, and Owen (1996). Active and inactive protein kinases: structural basis for regulation. Cell, 85:149-158.
Mayer (1995). Why two heads are better. Current Biology, 3:977-980. 2. 3.
Nitabach, M.N., Blau, J. and Holmes, T.C. (2002) Electrical silencing of central pacemaker neurons stops the central molecular clock. Cell 109:485-495
Palay, SL. The meaning of synaptics architecture. Ch. 4 (Pp 49-51) in K Fuxe and LF Agnati (eds.) Volume Transmission in the Brain: Novel Mechanisms for Neural Transmission, NY: Raven, 1991.
Peters, A, Palay, SL and Webster, HDeF.. The Fine Structure of the Nervous System: Neurons and Their Supporting Cells, 3rd ed., NY: Oxford, 1991. (Book in CNS Library.)
Sheng M, McFadden G and Greenberg ME. Membrane depolarization and calcium induce c-fos transcription via phosphorylation of transcription factor CREB. Neuron 1990 Apr;4(4):571-582.
Shi, S-H, Hayashi, Y, Petralla, RS, Zaman, SH, Wenthold, RJ, Svoboda, K and Manilow, R. Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation. Science, 1999, 284:1811-1816.
Smith, CUM. Chapters 15 and 16 (Pages 318-367) in Elements of Molecular Neurobiology, 2nd edition. New York: Wiley, 1996. (Handout)
Tu, JC, Xiao, B, Naisbitt, S, Yuan, JP, Petralla, RS, Brakeman, P, Doan, A, Aakalu, VK, Lanahan, AA, Sheng, M and Worley, PF. Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. Neuron, 1999, 23:583-592.van den Pol and Obrietan, (2002) Nature Neuroscience, 5: 616-618, News and Views.
Wickman, K and Clapham, DE. Ion channel regulation by G proteins. Physiological Reviews, 1995, 75:865-
Ziff, E. Enlightening the postsynaptic density. Neuron, 1997, 19:1163-1174.
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