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The LeDoux Lab

Center for Neural Science at NYU





  • Virginia Woolf

    "My own brain is to me the most unaccountable of machinery-- always buzzing, humming, soaring roaring diving, and then buried in mud. And why? What's this passion for?"

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  • Our Team

    Check out who we are and what we do

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  • Coming to terms with fear - Joseph LeDoux

    Research on Pavlovian fear conditioning has been very successful in revealing what has come to be called the brain’s fear system. The field has now matured to the point where a sharper conceptualization of what is being studied could be very useful as we go forward......"

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  • Rethinking the Emotional Brain - Joseph LeDoux

    I propose a reconceptualization of key phenomena important in the study of emotion — those phenomena that reflect functions and circuits related to survival, and that are shared by humans and other animals......

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  • Nature 406, 722-726 (17 August 2000): Karim Nader, Glenn E. Schafe & Joseph E. LeDoux

    Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval

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  • Science Magazine 15 May 2009 Vol. 324, Monfils et al., 324 (5929): 951-955

    Extinction-Reconsolidation Boundaries: Key to Persistent Attenuation of Fear Memories

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  • PNAS vol. 107 no. 28 > Joshua P. Johansen, 12692–12697 h2>

    Optical activation of lateral amygdala pyramidal cells instructs associative fear learning

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  • Joseph E. LeDoux (2008), Scholarpedia, 3(4):2698. h2>

    Amygdala

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  • Threat-induced Defensive Reactions h2>

    Pavlovian defense conditioning, more commonly known as fear conditioning.

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  • View Joseph LeDoux's Curriculum Vitae (PDF)

    Download LeDoux's photos and Bio
  • THE EMOTIONAL BRAIN

    The Mysterious underpinnings of emotional Life.
  • SYNAPTIC SELF

    How Our Brains Become Who We Are.
  • LeDouxlab Journal Club
  • NYU Memory RESEARCH Group
  • The Emotional Brain Institute
    • EBI MISSION
    • EBI MEMBERS
    • EBI NEWS AND EVENTS
  • IN THE NEWS
    • August 20, 2014 - Scientific American : How Do Our Brains Remember? [Video] - Joe LeDoux interviews Eric Kande. By Mark Fischetti
    • June 30, 2014 - Scientific American : Free Will: Is Your Brain the Boss of You? [Video] - Joe LeDoux interviews Mike Gazzaniga on the topic of free will and the brain
    • Apr.10,2014 - " 7. 1996-2001: A Great Time to be in That Great Lab in That Great City" - Former postdoc Karim Nader shares his experience in the LeDoux lab in the 90's in this week's blog post
    • Joseph LeDoux has been named a recipient of the William James Fellow Award for 2015.
    • Feb. 26, 2014 - ROCK YOUR MIND! Brain Science and Rock Music Come Together to Shift Communication for Consciousness Science During Brain Awareness Week at The Bowery Electric---March 13
    • February 25, 2014 - PNAS/Science and Culture: The Amygdaloids by Stephen Ornes , Science Writer
    • February 10, 2014 - PNAS: QnAs with Joseph LeDoux by Prashant Nair
    • Janurary 13, 2014 - Finding Myself in The LeDoux Lab- Former postdoc Greg Quirk shares his experience in the LeDoux lab in the 90's in this week's blog post.
    • December 31, 2013 -Can Outliers Help Us Understand the Average Brain?- Former student, Dr. Kiriana Cowansage on the importance of individual differences.@ledouxlab.tumblr.com
    • December 22, 2013 -Pavlovian-to-Instrumental Transfer: How a Cue can Drive Behavior- Read Vinn Campese's poster on LeDoux Lab Blogosphere.
    • December 18, 2013 -Today we celebrate Dr. Hillary Schiff and her successful dissertation defense. Well done, Hillary! Congratulations Dr. Hillary Schiff ! We're so proud of you.
    • December 10, 2013 - "Gumbo, Fear and Rock-n-Roll - New Online Publication Covers the Emotional Brain and Reveals at Least One of Joe’s Little Secrets" . By JoAnna Klein@ledouxlab.tumblr.com
    • December 9, 2013 - "Joe LeDoux: The Emotional Brain, Gumbo and the Amygdaloids" - in the official newsletter of the International Society for Research on Emotion , Emotion Researcher, featured Joe LeDoux as the first interviewee of the series.
    • December 2, 2013 - "How the Prefrontal Cortex and the Amygdala Compete to Keep You Safe" - By Justin Moscarello -ledouxlab.tumblr.com
    • November 26, 2013 - " Development of an aversive Pavlovian-to-instrumental transfer task in rat" - Vincent Campese et at al. published a paper in Front. Behav. Neurosci.
    • November 25, 2013 - "Orexin/hypocretin system modulates amygdala- dependent threat learning through the locus coeruleus" - Robert M. Sears et al. published a paper in PNAS.
    • November 25, 2013 - "Extinction during reconsolidation of threat memory diminishes prefrontal cortex involvement" by Schiller et al. - A new paper, a collaboration with Phelps Lab at NYU, published in PNAS .
    • November 19, 2013 - The LeDoux Lab launches its blog on Tumblr with Joe's first post "An Emotional Brain Is a Hard Thing To Tame".
    • November 9, 2013 - LeDouxlab at 20013 SfN - Read our <Abstracts>
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  • PUBLICATIONS
    Vincent D Campese, Jeanny Kim, Gabriel Lazaro-Munoz, Lashawn Pena, Joseph E LeDoux and Christopher K Cain. Lesions of lateral or central amygdala abolish aversive Pavlovian-to-instrumental transfer in rats <Abstract><Full>

    Apergis-Schoute AM, Schiller D, Ledoux JE, Phelps EA.Extinction resistant changes in the human auditory association cortex following threat learning. <Abstract><Full>

    LeDoux JE. Coming to terms with fear.PNAS 2014:1400335111v1-201400335. <Abstract><Full>

    Sears RM,Schiff HC, Ledoux JE. Molecular mechanisms of threat learning in the lateral nucleus of the amygdala. Prog Mol Biol Transl Sci. 2014;122:263-304. doi: 10.1016/B978-0-12-420170-5.00010-6.<Abstract><Full>

    Ostroff LE, Manzur MK, Cain CK, Ledoux JE. Synapses lacking astrocyte appear in the amygdala during consolidation of Pavlovian threat conditioning.J Comp Neurol. 2013 Dec 12. doi: 10.1002/cne.23523. [Epub ahead of print]<Abstract><Full>

    Sears RM, Fink AE, Wigestrand MB, Farb CR, de Lecea L, LeDoux JE. Orexin/hypocretin system modulates amygdala-dependent threat learning through the locus coeruleus. Proc Natl Acad Sci.2013 Nov 25 <Abstract><Full>

    Vincent Campese, Margaret McCue, Gabriel Lazaro-Munoz, Joseph LeDoux and Christopher Cain. Development of an aversive Pavlovian-to-instrumental transfer task in rat. Front. Behav. Neurosci., 26 November 2013. <Abstrac><Full>

    Daniela Schiller, Jonathan W. Kanen, Joseph E. LeDoux,Marie-H. Monfils, and Elizabeth A. Phelps. Extinction during reconsolidation of threat memory diminishes prefrontal cortex involvementPNAS November 25, 2013 . <Abstract><Full>

    Martinez RC, Gupta N, Lázaro-Muñoz G, Sears RM, Kim S, Moscarello JM, Ledoux JE, Cain CK. Active vs. reactive threat responding is associated with differential c-Fos expression in specific regions of amygdala and prefrontal cortex. Learn Mem. 2013 Jul 18;20(8):446-52. <Abstract><Full>


    Galatzer-Levy IR, Bonanno GA, Bush DE, LeDoux JE. Heterogeneity in threat extinction learning: substantive and methodological considerations for identifying individual difference in response to stress. Front Behav Neurosci. 2013 May 29;7:55.<Abstract><Full>


    LeDoux JE. The slippery slope of fear. Trends Cogn Sci. 2013 Apr;17(4):155-6. <Abstract><Full>


    Moscarello JM, Ledoux JE. Active avoidance learning requires prefrontal suppression of amygdala-mediated defensive reactions. J Neurosci. 2013 Feb 27;33(9):3815-23. <Abstract><Full>


    Díaz-Mataix L, Ruiz Martinez RC, Schafe GE, Ledoux JE, Doyère V. Detection of a Temporal Error Triggers Reconsolidation of Amygdala-Dependent Memories. Curr Biol. 2013 Mar 18;23(6):467-72. <Abstract><Full>

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  • JOSEPH LEDOUX ON BIG THINK
    • The Amygdala in 5 Minutes
    • Why Study Animals’ Brains?
    • When To Trust Your Memory
    • What Causes Extreme Fear in the Brain ?
    • The Amygdala and Unconscious Memories

SLIDESHOW LECTURES

  • »Fear in the age of terror
  • »Remembering fear
  • » Long-term potentiation in the lateral nucleus of the amygdala
  • » Fearful brain in an anxious world
  • » Fearful brain in an anxious world (Audio)

vIDEO CLIPS

  • » Experimenta: Conversation with Joseph LeDoux About My Mind’s Eye
  • » What Is Consciousness? Go to the Video!
  • » The Emotional Brain(October 2011, University of Sydney)
  • » Our emotional brains (2011 Copernicus Center Lecture )
  • » The Emotional Brain (May 20, 2011, Kraków, Poland)
  • » What fearful rats can tell us about treating psychiatric disorders
  • » Fear: Replacing Memories
  • » Joseph LeDoux on The Emotional Brain

Artist in Residence

  • » Mapping Series 2013
  • » The Plain Sense of Things
  • » Circling the Center
  • » Shadow Speech
  • » Field of Vision(for Mary)
  • » Small Worlds
  • »Smallworlds(cerebrum)
  • » Loculus
  • » Works on Paper

The Amygdaloids

  • » The band
  • » News
  • » Gigs
  • » Music/Lyrics
  • » Video
  • » Press/Blogs
  • »Store

FEARING

Written by Joseph LeDoux (based on Emily Dickinson,PDF), Performed by The AMYGDALOIDS
Sell your beats online at ReverbNation.com



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