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Kenway Louie
|
Curriculum Vitae
|
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Center for Neural Science
New York University 4 Washington Place, Room 809 New York, NY 10003 |
Research
interests
|
Neurobiology of decision-making, rational and irrational choice behavior, computational analysis of cortical algorithms, efficient coding in neural value representations |
Education
|
Harvard Medical School M.D. cum laude |
1993-2004 |
Massachusetts Insitute of
Technology Ph.D. in Biology |
1995-2002 |
Massachusetts Insitute of
Technology S.B. in Biology, S.B. in Chemical Engineering |
1989-1993 |
Honors
and Awards
|
Ruth L. Kirschstein National Research Service Award Individual Fellowship | 2006-2008 |
Dr. Sirgay Sanger Prize, best paper
in psychiatry, Harvard Medical School |
2004 |
Harvard Medical School, Cum Laude | 2004 |
NIH GMS Medical Scientist
Training Program |
2002-2004 |
Whitehead Undergraduate
Research Award, Massachusetts Institute of Technology |
1993 |
Tau Beta Pi, Phi Beta Kappa | 1993 |
Professional
Service
|
Society
Governance |
Board Member, Society for
Neuroeconomics 2017-2020 Program Committee Co-Chair, Society for Neuroeconomics 2018-2020 |
Conference organization |
Program committee member,
Society for Neuroeconomics Meeting 2017-2018 |
Program committee member,
Computational and Systems Neuroscience Meeting 2015 |
Minisymposium organizer, Society
for Neuroscience Annual Meeting 2011 Context-dependent neural representations of value: gain control, adaptation, and efficient coding |
Ad hoc reviewer |
Cognitive Affective and Behavioral Neuroscience, Decision, eLife, eNeuro, Frontiers in Behavioral Neuroscience, Journal of Neuroscience, Journal of Neurophysiology, Nature Communications, Nature Human Behaviour, Nature Neuroscience, Neural Networks, Neuron, PNAS, Science, Psychological Review, Scientific Reports |
Professional affiliations |
Society for Neuroscience, 1996-present |
Society for Neuroeconomics, 2005-present |
Research
Experience
|
Research Assistant Professor,
Center for Neural Science, New
York University Normalization, network dynamics, and population coding in decision and valuation circuitry |
2012-present |
Postdoctoral Fellow, Center for Neural Science, New
York University Principal Investigator: Prof. Paul W. Glimcher, Ph.D. Single unit electrophysiology of decision-making and neuroeconomics, neuronal mechanisms of valuation circuitry |
2004-2012 |
Predoctoral Fellow, Department of Biology, Massachusetts Insitute of
Technology Principal Investigator: Prof. Matthew A. Wilson Multi-channel recording, hippocampal pattern reactivation, memory formation |
1995-2002 |
Research Assistant, Department of Genetics, Harvard
Medical School Principal Investigator: Prof. David Beier, M.D., Ph.D. Cloning analysis of murine model of polycystic kidney disease |
1994-1995 |
Research Assistant, Department of Biology, Massachusetts Insitute of
Technology Principal Investigator: Prof. Robert A. Weinberg, Ph.D. Biochemical investigation of interaction between cell cycle and tumor suppressor proteins |
1994-1995 |
Teaching
Experience
|
New York University, Center for Neural Science Course organizer and lecturer, Honors Seminar (NEURL UA-301) |
2012-2017 |
Champalimaud
Foundation
Neuroscience Progam, Lisbon, Portugal Course organizer and lecturer, graduate sensory systems class |
2009-2012 |
Massachusetts
Institute of
Technology, Department of
Biology Teaching assistant, Human Physiology Teaching assistant, Cellular Neurophysiology |
1998 1996 |
Publications
|
Peer reviewed journal articles |
Louie K, Glimcher PW. Adaptive value coding and the optimality of choice. (In preparation) |
Konova AB, Lopez-Guzman S, Urmanche A, Ross S, Louie K, Rotrosen J, Glimcher PW. Computational markers of risky becision-making identify temporal windows of vulnerability to use opioids: a longitudinal study in a real-world clinical setting. (Under review) |
Steverson K, Chung H-K, Zimmermann J, Louie K, Glimcher PW. The costs of time: testing evidence accumulation models of value-based decision making. (Under review) |
Webb R, Louie K, Glimcher PW. Rationalizing context-dependent preferences: divisive normalization and neural constraints. (Under review) |
Cohen D, Teichman G, Volovich M, Zeevi Y, Louie K, Levy DJ, Rechavi O. Bounded rationality in C. elegans is explained by circuit-specific normalization in chemosensory pathways. Nat Commun, in press. |
Zimmermann J, Glimcher PW, Louie K. Multiple timescales of normalized value coding underlie adaptive choice behavior. Nat Commun, 9: 3206 (2018) |
Konova
AB, Louie
K, Glimcher PW. The computational form of craving: selective
multiplication of economic value. Proc
Natl Acad Sci U S A, 115: 4122-4127 (2018) |
Lopez-Guzman
S, Konova AB, Louie
K, Glimcher PW. Risk preferences impose a hidden distortion on
measures of choice impulsivity. PloS
one 13(1): e0191357 (2018) |
Yamada H, Louie K, Tymula A, Glimcher PW. Free choice shapes normalized value signals in medial orbitofrontal cortex. Nat Commun, 9 (2018) |
Khaw
MW, Glimcher PW, Louie
K. Normalized value coding explains dynamic adaptation in the human
valuation process. Proc Natl Acad
Sci U S A, 114: 12696-12701 (2017) |
Holper L, Van Brussel LD, Schmidt L, Schulthess S, Burke CJ, Louie K, Seifritz E, Tobler PN. Adaptive normalization in the prefrontal cortex is reduced by memory load. eNeuro, 4(2): ENEURO.0365-17.2017 (2017) |
Zimmermann
J, Vazquez Y, Glimcher PW, Pesaran B, Louie K. Oculomatic: High
speed, reliable, and accurate open-source eye tracking for humans and
non-human primates. J Neurosci Methods, 270: 138-146 (2016) |
Louie K, LoFaro T, Webb R,
Glimcher
PW. Dynamic divisive normalization predicts time-varying value coding
in decision-related circuits. J
Neurosci, 34: 16046-16057 (2014) |
LoFaro T, Louie K, Webb R, Glimcher PW. The temporal dynamics of cortical normalization models of decision-making. Lett Biomath, 1: 209-220 (2014) |
Yamada H, Tymula A, Louie K, Glimcher PW. Thirst-dependent risk preferences in monkeys identify a primitive form of wealth. Proc Natl Acad Sci U S A, 110: 15788-15793 (2013) |
Louie K, Khaw MW, Glimcher PW. Normalization is a general neural mechanism for context-dependent decision making. Proc Natl Acad Sci U S A, 110: 6139-6144 (2013) |
Louie
K, Grattan L, Glimcher, PW. Reward value-based gain
control: divisive normalization in parietal cortex. J Neurosci,
31: 10627-10639 (2011) |
Yamada H, Louie K, Glimcher PW. Controlled water intake: a method for objectively evaluating thirst and hydration state in monkeys by the measurement of blood osmolality. J Neurosci Methods, 191: 83-89 (2010) |
Louie K, Glimcher PW. Separating value from choice: delay discounting activity in the lateral intraparietal area. J Neurosci, 30: 5498-5507 (2010) |
Louie
K, Wilson
MA. Temporally structured replay
of awake hippocampal ensemble activity during rapid eye movement sleep.
Neuron, 29: 145-156 (2001) |
Dowdy SF, Hinds PW, Louie
K, Reed SI, Arnold A, Weinberg RA. Physical interaction
of the retinoblastoma protein with human D cyclins. Cell,
73: 499-511 (1993) |
Other writing |
Louie
K, Glimcher PW. Normalization principles in computational
neuroscience. Oxford Research
Encyclopedia of Neuroscience (2019) |
Louie
K, Glimcher PW. Computational principles of value coding in the
brain. In Decision Neuroscience.
Dreher JC and Tremblay L, eds. Academic Press (2016) |
Louie
K, Glimcher PW, Webb R. Adaptive neural coding: from biological
to behavioral decision-making. Curr
Opin Behav Sci, 5:91:99 (2015) |
Louie
K. Exploiting exploration: past outcomes and future actions. Neuron, 80: 6-9 (2013) |
Louie
K. Integrating salience and value in decision making. Proc Natl Acad Sci U S A, 110:
15853-15854 (2013) |
Louie
K, de Martino B. The neurobiology of context-dependent
valuation and choice. In Neuroeconomics:
Decision Making and the Brain. 2nd ed. Glimcher PW and Fehr E,
eds. Academic Press (2013) |
Paton JJ, Louie
K. Reward and punishment illuminated. Nat Neurosci, 15: 807-809 (2012) |
Louie K, Glimcher PW. Efficient coding and the neural representation of value. Ann N Y Acad Sci, 1251: 13-32 (2012) |
Louie
K, Glimcher PW. Set size effects and the neural
representation of
value. In Neuroscience of Preference and Choice. Dolan R
and Sharot T. eds. Elsevier (2011) |
Glimcher PW, Kable JW, Louie K. Neuroeconomic studies of impulsivity: now or just as soon as possible? American Economic Review, 97: 142-147 (2007) |
Madsen JR, Louie K. Nonresective surgical management of refractory epilepsy: callosotomy and vagal stimulation. In Principles and Practice of Pediatric Neurosurgery, Albirght L et al. eds., 1096-1114 (2007) |
Louie K. Mnemonic Information in the Rodent Hippocampus During Wake and Sleep States (Doctoral dissertation). Massachusetts Institute of Technology, Cambridge, MA (2002) |
Select
Presentations
|
From suboptimal to optimal choice: contextual value coding and adaptive decision making. Invited talk, New York State Psychiatric Institute in New York, NY. October 2018. |
Adaptive value coding in brain and behavior. Invited talk, Neuroeconomics and the Evolution of Economic Behavior Conference in Vancouver, Canada. May 2018. |
Multiple timescales of valuation mediate adaptive choice behavior. Selected talk, Society for Neuroeconomics meeting in Berlin, Germany. August 2016. |
Adaptive value coding and context-dependent choice. Invited talk, Symposium on Biology of Decision-Making in Paris, France. May 2015. |
Adaptive
value coding and the optimality of choice. Selected talk, Society for Neuroscience meeting in Washington, D.C. November 2014. |
A
dynamical model of normalization: the interaction between time, value,
and choice. Selected talk, Society for Neuroeconomics meeting in Miami, FL. September 2014. |
Rapid
temporal dynamics of value normalization in parietal cortex. Poster, Society for Neuroscience meeting in San Diego, CA. November 2013. |
Neural
variability and normalization drive biphasic context-dependence in
decision-making. Selected talk, Computational and Systems Neuroscience meeting in Salt Lake City, UT. March 2013. |
Cortical
normalization is a general neural mechanism for context-dependent
choice. Selected talk, Society for Neuroscience meeting in New Orleans, LA. October 2012. |
Computational
models of stochastic
choice behavior in value-guided decision-making. Selected talk, Society for Neuroeconomics meeting in Evanston, IL. September 2011. |
The
effect of value
normalization and cortical variability on rational choice. Poster, Society for Neuroscience meeting in San Diego, CA. November 2010. |
Decision,
value, and context: divisive normalization and relative reward coding. Invited talk, University College London, Functional Imaging Laboratory. December 2009. |
Divisive
normalization and relative reward representation in parietal cortex. Invited talk, California Institute of Technology, Brain, Mind, and Society seminar. October 2009. |
Value-based
gain control: relative reward normalization in parietal cortex. Selected talk, Society for Neuroeconomics meeting in Park City, UT. September 2008. |
Temporal
discounting activity in parietal neurons during intertemporal choice. Selected talk, Computational and Systems Neuroscience meeting in Salt Lake City, UT. March 2006. |
Intertemporal
choice behavior in monkeys: interaction between delay to reward,
subjective value, and area LIP. Poster, Society for Neuroscience meeting in Washington, D.C. November, 2005. |
Temporally-structured
reactivation of hippocampal patterns during REM sleep. Invited talk, American Professional Sleep Society meeting in Seattle, WA. June 2002. |
Reward
bias of neuronal activity in the rodent hippocampus. Poster, Society for Neuroscience meeting in San Diego, CA. November 2001. |
Temporally
structured REM sleep replay of awake hippocampal ensemble activity. Selected talk, Society for Neuroscience meeting in New Orleans, LA. October 2000. |