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Kenway Louie
Curriculum Vitae


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(212) 998-3904
(212) 995-4011
klouie@cns.nyu.edu
http://www.cns.nyu.edu/~klouie
Center for Neural Science
New York University
4 Washington Place, Room 809
New York, NY 10003

Research interests
Neurobiology of decision-making, rational and irrational choice behavior, computational analysis of cortical algorithms, efficient coding in neural value representations

Education
Harvard Medical School
M.D. cum laude
1993-2004
Massachusetts Insitute of Technology
Ph.D. in Biology
1995-2002
Massachusetts Insitute of Technology
S.B. in Biology, S.B. in Chemical Engineering
1989-1993

Honors and Awards
Ruth L. Kirschstein National Research Service Award Individual Fellowship 2006-2008
Dr. Sirgay Sanger Prize, best paper in psychiatry, Harvard Medical School
2004
Harvard Medical School, Cum Laude 2004
NIH GMS Medical Scientist Training Program
2002-2004
Whitehead Undergraduate Research Award, Massachusetts Institute of Technology
1993
Tau Beta Pi, Phi Beta Kappa 1993

Professional Service
Society Governance
Board Member, Society for Neuroeconomics 2017-2020
Program Committee Co-Chair, Society for Neuroeconomics 2018-2020

Conference organization

Program committee member, Society for Neuroeconomics Meeting 2017-2018
Program committee member, Computational and Systems Neuroscience Meeting 2015
Minisymposium organizer, Society for Neuroscience Annual Meeting 2011
Context-dependent neural representations of value: gain control, adaptation, and efficient coding

Ad hoc reviewer
Cognitive Affective and Behavioral Neuroscience, Decision, eLife, eNeuro, Frontiers in Behavioral Neuroscience, Journal of Neuroscience, Journal of Neurophysiology, Nature Communications, Nature Human Behaviour, Nature Neuroscience, Neural Networks, Neuron, PNAS, Science, Psychological Review, Scientific Reports

Professional affiliations

Society for Neuroscience, 1996-present
Society for Neuroeconomics, 2005-present

Research Experience
Research Assistant Professor, Center for Neural Science, New York University
Normalization, network dynamics, and population coding in decision and valuation circuitry
2012-present
Postdoctoral Fellow, Center for Neural Science, New York University
Principal Investigator: Prof. Paul W. Glimcher, Ph.D.
Single unit electrophysiology of decision-making and neuroeconomics, neuronal mechanisms of valuation circuitry
2004-2012
Predoctoral Fellow, Department of Biology, Massachusetts Insitute of Technology
Principal Investigator: Prof. Matthew A. Wilson
Multi-channel recording, hippocampal pattern reactivation, memory formation
1995-2002
Research Assistant, Department of Genetics, Harvard Medical School
Principal Investigator: Prof. David Beier, M.D., Ph.D.
Cloning analysis of murine model of polycystic kidney disease
1994-1995
Research Assistant, Department of Biology, Massachusetts Insitute of Technology
Principal Investigator: Prof. Robert A. Weinberg, Ph.D.
Biochemical investigation of interaction between cell cycle and tumor suppressor proteins
1994-1995

Teaching Experience
New York University, Center for Neural Science
Course organizer and lecturer, Honors Seminar (NEURL UA-301)
2012-2017
Champalimaud Foundation Neuroscience Progam, Lisbon, Portugal
Course organizer and lecturer, graduate sensory systems class
2009-2012
Massachusetts Institute of Technology, Department of Biology
Teaching assistant, Human Physiology
Teaching assistant, Cellular Neurophysiology

1998
1996

Publications
Peer reviewed journal articles
Louie K, Glimcher PW. Adaptive value coding and the optimality of choice. (In preparation)
Konova AB, Lopez-Guzman S, Urmanche A, Ross S, Louie K, Rotrosen J, Glimcher PW. Computational markers of risky becision-making identify temporal windows of vulnerability to use opioids: a longitudinal study in a real-world clinical setting. (Under review)
Steverson K, Chung H-K, Zimmermann J, Louie K, Glimcher PW. The costs of time: testing evidence accumulation models of value-based decision making. (Under review)
Webb R, Louie K, Glimcher PW. Rationalizing context-dependent preferences: divisive normalization and neural constraints. (Under review)
Cohen D, Teichman G, Volovich M, Zeevi Y, Louie K, Levy DJ, Rechavi O. Bounded rationality in C. elegans is explained by circuit-specific normalization in chemosensory pathways. Nat Commun, in press.
Zimmermann J, Glimcher PW, Louie K. Multiple timescales of normalized value coding underlie adaptive choice behavior. Nat Commun, 9: 3206 (2018)
Konova AB, Louie K, Glimcher PW. The computational form of craving: selective multiplication of economic value. Proc Natl Acad Sci U S A, 115: 4122-4127 (2018)
Lopez-Guzman S, Konova AB, Louie K, Glimcher PW. Risk preferences impose a hidden distortion on measures of choice impulsivity. PloS one 13(1): e0191357 (2018)
Yamada H, Louie K, Tymula A, Glimcher PW. Free choice shapes normalized value signals in medial orbitofrontal cortex. Nat Commun, 9 (2018)
Khaw MW, Glimcher PW, Louie K. Normalized value coding explains dynamic adaptation in the human valuation process. Proc Natl Acad Sci U S A, 114: 12696-12701 (2017)
Holper L, Van Brussel LD, Schmidt L, Schulthess S, Burke CJ, Louie K, Seifritz E, Tobler PN. Adaptive normalization in the prefrontal cortex is reduced by memory load. eNeuro, 4(2): ENEURO.0365-17.2017 (2017)
Zimmermann J, Vazquez Y, Glimcher PW, Pesaran B, Louie K. Oculomatic: High speed, reliable, and accurate open-source eye tracking for humans and non-human primates. J Neurosci Methods, 270: 138-146 (2016)
Louie K, LoFaro T, Webb R, Glimcher PW. Dynamic divisive normalization predicts time-varying value coding in decision-related circuits. J Neurosci, 34: 16046-16057 (2014)
LoFaro T, Louie K, Webb R, Glimcher PW. The temporal dynamics of cortical normalization models of decision-making. Lett Biomath, 1: 209-220 (2014)
Yamada H, Tymula A, Louie K, Glimcher PW. Thirst-dependent risk preferences in monkeys identify a primitive form of wealth. Proc Natl Acad Sci U S A, 110: 15788-15793 (2013)
Louie K, Khaw MW, Glimcher PW. Normalization is a general neural mechanism for context-dependent decision making. Proc Natl Acad Sci U S A, 110: 6139-6144 (2013)
Louie K, Grattan L, Glimcher, PW. Reward value-based gain control: divisive normalization in parietal cortex. J Neurosci, 31: 10627-10639 (2011)
Yamada H, Louie K, Glimcher PW. Controlled water intake: a method for objectively evaluating thirst and hydration state in monkeys by the measurement of blood osmolality. J Neurosci Methods, 191: 83-89 (2010)
Louie K, Glimcher PW. Separating value from choice: delay discounting activity in the lateral intraparietal area. J Neurosci, 30: 5498-5507 (2010)
Louie K, Wilson MA. Temporally structured replay of awake hippocampal ensemble activity during rapid eye movement sleep. Neuron, 29: 145-156 (2001)
Dowdy SF, Hinds PW, Louie K, Reed SI, Arnold A, Weinberg RA. Physical interaction of the retinoblastoma protein with human D cyclins. Cell, 73: 499-511 (1993)

Other writing
Louie K, Glimcher PW. Normalization principles in computational neuroscience. Oxford Research Encyclopedia of Neuroscience (2019)
Louie K, Glimcher PW. Computational principles of value coding in the brain. In Decision Neuroscience. Dreher JC and Tremblay L, eds. Academic Press (2016)
Louie K, Glimcher PW, Webb R. Adaptive neural coding: from biological to behavioral decision-making. Curr Opin Behav Sci, 5:91:99 (2015)
Louie K. Exploiting exploration: past outcomes and future actions. Neuron, 80: 6-9 (2013)
Louie K. Integrating salience and value in decision making. Proc Natl Acad Sci U S A, 110: 15853-15854 (2013)
Louie K, de Martino B. The neurobiology of context-dependent valuation and choice. In Neuroeconomics: Decision Making and the Brain. 2nd ed. Glimcher PW and Fehr E, eds. Academic Press (2013)
Paton JJ, Louie K. Reward and punishment illuminated. Nat Neurosci, 15: 807-809 (2012)
Louie K, Glimcher PW. Efficient coding and the neural representation of value. Ann N Y Acad Sci, 1251: 13-32 (2012)
Louie K, Glimcher PW. Set size effects and the neural representation of value.  In Neuroscience of Preference and Choice. Dolan R and Sharot T. eds. Elsevier (2011)
Glimcher PW, Kable JW, Louie K. Neuroeconomic studies of impulsivity: now or just as soon as possible? American Economic Review, 97: 142-147 (2007)
Madsen JR, Louie K. Nonresective surgical management of refractory epilepsy: callosotomy and vagal stimulation. In Principles and Practice of Pediatric Neurosurgery, Albirght L et al. eds., 1096-1114 (2007)
Louie K. Mnemonic Information in the Rodent Hippocampus During Wake and Sleep States (Doctoral dissertation). Massachusetts Institute of Technology, Cambridge, MA (2002)

Select Presentations
From suboptimal to optimal choice: contextual value coding and adaptive decision making.
Invited talk, New York State Psychiatric Institute in New York, NY. October 2018.
Adaptive value coding in brain and behavior.
Invited talk, Neuroeconomics and the Evolution of Economic Behavior Conference in Vancouver, Canada. May 2018.
Multiple timescales of valuation mediate adaptive choice behavior.
Selected talk, Society for Neuroeconomics meeting in Berlin, Germany. August 2016.
Adaptive value coding and context-dependent choice.
Invited talk, Symposium on Biology of Decision-Making in Paris, France. May 2015.
Adaptive value coding and the optimality of choice.
Selected talk, Society for Neuroscience meeting in Washington, D.C. November 2014.
A dynamical model of normalization: the interaction between time, value, and choice.
Selected talk, Society for Neuroeconomics meeting in Miami, FL. September 2014.
Rapid temporal dynamics of value normalization in parietal cortex.
Poster, Society for Neuroscience meeting in San Diego, CA. November 2013.
Neural variability and normalization drive biphasic context-dependence in decision-making.
Selected talk, Computational and Systems Neuroscience meeting in Salt Lake City, UT. March 2013.
Cortical normalization is a general neural mechanism for context-dependent choice.
Selected talk, Society for Neuroscience meeting in New Orleans, LA. October 2012.
Computational models of stochastic choice behavior in value-guided decision-making.
Selected talk, Society for Neuroeconomics meeting in Evanston, IL. September 2011.
The effect of value normalization and cortical variability on rational choice.
Poster, Society for Neuroscience meeting in San Diego, CA. November 2010.
Decision, value, and context: divisive normalization and relative reward coding.
Invited talk, University College London, Functional Imaging Laboratory. December 2009.
Divisive normalization and relative reward representation in parietal cortex.
Invited talk, California Institute of Technology, Brain, Mind, and Society seminar. October 2009.
Value-based gain control: relative reward normalization in parietal cortex.
Selected talk, Society for Neuroeconomics meeting in Park City, UT. September 2008.
Temporal discounting activity in parietal neurons during intertemporal choice.
Selected talk, Computational and Systems Neuroscience meeting in Salt Lake City, UT. March 2006.
Intertemporal choice behavior in monkeys: interaction between delay to reward, subjective value, and area LIP.
Poster, Society for Neuroscience meeting in Washington, D.C. November, 2005.
Temporally-structured reactivation of hippocampal patterns during REM sleep.
Invited talk, American Professional Sleep Society meeting in Seattle, WA. June 2002.
Reward bias of neuronal activity in the rodent hippocampus.
Poster, Society for Neuroscience meeting in San Diego, CA. November 2001.
Temporally structured REM sleep replay of awake hippocampal ensemble activity.
Selected talk, Society for Neuroscience meeting in New Orleans, LA. October 2000.